Evaluation of Anti-inflammatory Activity of the Leaf Extracts of Solanum Trilobatum Linn

Methanol extracts of Solanum trilobatum Linn Leaf were investigated for anti-inflammatory activity with acute and chronic models. In the doses of 100, 200 and 300 mg kgexhibited significant (P < 0.05) anti-inflammatory activity in all the models tested. The methanol extracts of Solanum trilobatum Linn at 300 mg kg showed maximum inhibition of 54.44 % in carrageenan-induced rat paw oedema while the standard drug indomethacin was 57.08 % after 3 hrs of carrageenan injection. On the other hand at 100, 200 and 300 mg kg inhibited with dextran, histamine and serotonin-induced rat paw oedema significantly and dose-dependently compared with control group. In the chronic inflammatory model, at 200 and 300 mg kg inhibited the granuloma weight by 22.65 %, whereas the indomethacin inhibited 28.37 %.